I would highly recommend using a Wine manager program such as PlayOnLinux. You can have each program in its own virtual drive and can use different wine versions and tweaks for each program. It'll manage the wine versions in the app so you don't have to install it systemwide.
Also check out https://appdb.winehq.org and https://protondb.com for compatibility, tweaks, etc. for each program.
I would highly recommend using a Wine manager program such as PlayOnLinux. You can have each program in its own virtual drive and can use different wine versions and tweaks for each program. It'll manage the wine versions in the app so you don't have to install it systemwide.
Also check out https://appdb.winehq.org and https://protondb.com for compatibility, tweaks, etc. for each program.