I have been flip-flopping between so many different setups lately, but I have yet to find the one. I am currently trying Gnome out, and while I don't think it feels as bad as I was led to believe there are a couple of removedling issues that keep me from committing totally.
GNOME gets a lot of hate for various reasons, but I really like it and don't really see myself giving it up anytime soon, I like it maybe a little too much... It looks pretty good out of the box, it has a really nice workflow once you get used to it, it has tons of extensions to change things you may not like or to add completely new things, it has a nice ecosystem of apps (GNOME Circle), and tons more. Though, I really dislike their decision of not wanting to support server-side decorations for clients, but it's a relatively small problem and it's whatever at the end of the day.
tldr: I use GNOME.
GNOME is the death metal of DEs to me in that I respect what they're doing and see why a lot of people like it, but it doesn't appeal to me at all.
I do appreciate how simple integration of Gnome is with Guix; it's a few service type fields, only a couple of lines, and it's ready to go. I want to give it a more prolonged shot, this time around. I will say I don't really like how they keep pushing "the Gnome way" thing, and for all their enthusiasm for flatpaks I have recently run into a very specific and irritating problem with Gnome shell's application menu and Gnome apps installed through flatpak, wherein they simply do not launch. They display just fine, the .desktop exec= lines work when pasted into a terminal window, and rofi's drun mode launches them...I don't know what on earth causes this and it is very frustrating to troubleshoot since I don't know where that particular messaging lives, and everything works dandy via command line. Regardless of that it is a very smooth experience and they really do have the look and feel nailed, imo.