Lord of the Rings and the Forgotten Realms are fine, they take up a set that could be a new plane or an expansion of an existing one but at least it's thematic sword fantasy. But add to that, Fallout, Warhammer 40k, Doctor Who, Transformers and some I probably forgot, it starts to be a bit much (most of those are Commander only I think, but still...)

If that was all restricted to Secret Lairs, low volume, collector bonuses, it wouldn't be a big deal, but no, you need to have Optimus Prime fighting a Hive Tyrant