Most of my exposure with anime was whatever was on Toonami and Adult Swim in the 2000s. I've not watched stuff like, Ghost In The Shell, Cowboy Bebop (only disjointed episodes out of order), Neon Genesis Evangelion, which I know are highly regarded.
I've seen just about every Miyazaki movie at this point. I've seen Akeria.
I'm sure there's more mainstream shows and non mainstream shows that I'm missing and would enjoy.
Thoughts?
boondocks is excellent on its own even if you don't like other anime, but if you do like other anime watch some of the stuff that influenced it to pick up on the homages.
Having Samuel L. Jackson voice the whitest character in the show was a masterstroke. The MF DOOM soundtrack.
The George W Bush and Rumsfeld analogy starting a random conflict in an Iraqi convenience store because they wanted to shoplift in broad daylight and bullying a cop named Officer French to side against the Iraqi shopkeeper while they were supposed to be doing something completely different is just chefs kiss
I would also recommend the entire blaxploitation genre of American film