Which factions should I ally with and which should I punch into the sun with my glorious unarmed cyborg?
As far as I remember, The Followers of the Apocalypse are cool, The Kings are funny and the NCR are lame military neolibs that use prison labour.
Oh, and I'm curbstomping Caesar the first chance I get.
If they're not the NCR, the Brotherhood of Steel or the Legion, they're usually okay
It's not really worth wiping out the Mojave BoS. They suck but they have no political power. Veronica and Christine probably wouldn't be happy if you killed everyone they knew.