Which factions should I ally with and which should I punch into the sun with my glorious unarmed cyborg?
As far as I remember, The Followers of the Apocalypse are cool, The Kings are funny and the NCR are lame military neolibs that use prison labour.
Oh, and I'm curbstomping Caesar the first chance I get.
I like to get all of the minor factions to like me, and then align them with Yes Man. This creates the most stable and powerful version of Independent Vegas, which I think is necessary for them to be able to resist the NCR or Legion if they decide to come back again.