Which factions should I ally with and which should I punch into the sun with my glorious unarmed cyborg?
As far as I remember, The Followers of the Apocalypse are cool, The Kings are funny and the NCR are lame military neolibs that use prison labour.
Oh, and I'm curbstomping Caesar the first chance I get.
It's not really worth wiping out the Mojave BoS. They suck but they have no political power. Veronica and Christine probably wouldn't be happy if you killed everyone they knew.