I've been using PipeWire this year on my Void Linux laptop & desktop. It's been mostly OK but has a few problems. For years I have been using plain ALSA (with no custom configuration) because pulseaudio causes me regular issues across multiple machines (mostly silently failing).

Pros:

• I don't have to use Chromium for my mic to work on online video conf (WTF Firefox)
• "EasyEffects" lets me quickly fix crappy youtube audio (bad gain normalisation, way too much sibilance) with a minimum of effort.

Cons:

• Sometimes breaks all audio until I manually restart it (hey, just like pulseaudio. This problem never happens when using ALSA straight)
• First time setup is complicated, involving environment variables, dbus user session buses and multiple daemons (running just pipewire isn't enough). Why can't it handle this all itself? Surely it should notice if these things are missing and just fix it itself? Compare this to straight ALSA where you (1) do nothing and then (2) everything works (except Firefox mic support)
• I can't have multiple audio outputs all unmuted at the same time. Eg my headphone output and my rear speaker output. If I override this (using alsamixer) then it gets forgotten next boot anyway, it seems to be out of scope of PipeWire's understanding.