I completed the Xbox 360 version of Read Dead Redemption on Xenia Canary some months back with the only enhancements being a 60 FPS unlock patch (I don't think my rig ever really hit 60, in empty wilderness scenes I got around 40-55 FPS and in towns and heavy combat I got maybe 22-30) as well as some antialiasing and smoothing filters applied to hide jaggies since I didn't think my RX 6600 could've handled resolution upscaling.
I still have Undead Nightmare to beat, but the PS4 and Switch versions got announced while I was getting to the end of the main game, and now that they're out I'm wondering if I should try Switch emulation for the DLC.
I did some quick googling and it seems emulating the Switch version on RyujinX has better performance visuals and less graphics glitches than Xbox 360 emulation, but I'm not sure if my Ryzen 5 5600 and RX 6600 are enough to make it a better option than the 720p with unstable FPS and lighting glitches you get on Xenia.
It depends a lot on the game. I've played a lot of switch games with no problems on my 12600k and 6800xt. The new Zelda game was really hard to play, though, even with all of the various performance tweaks and mods available 3 months after the launch. Frame rate drops, glitches, timing flaws, bugs, etc. It's probably in a better state now, but I got sick of trying the latest settings and mods and still having issues.