I first used Linux about 5 years ago (Ubuntu). Since then, I have tried quite a few distros:
Kali Linux (Use as a secondary)
Linux Mint (Used for a while)
Arch Linux (Could not install)
Tails (Use this often)
Qubes OS (Tried it twice, not ready yet)
Fedora (Current main)
For me, it has been incredibly difficult to find a properly privacy oriented Linux distro that also has ease of use. I really enjoy the GNOME desktop environment, and I am most familiar with Debian. My issue with Fedora is the lack of proper sandboxing, and it seems as though Qubes is the only one that really takes care in sandboxing apps.
Apologies if this is the wrong community for this question, I would be happy to move this post somewhere else. I've been anonymously viewing this community after the Rexodus, but this is my first time actually creating a post. Thank you!
If the distro supports apparmor, then firejail + apparmor offer together sandboxing for quite a set of applications (apparmor includes few profiles by itself, but firejal has quite a few, and one can enable apparmor on all, or the ones wnated). Arch has pretty good wikies about firejail + apparmor.