I have a specific issue I want to solve right now, but the topic is phrased more generally as I would love the answer to this as well. But this might be an XY-problem because of this, so here's the actual problem I want to solve:
I am using LibreWolf as my main browser, and it has WebGL disabled by default to avoid fingerprinting. I would like to keep it this way, but I am currently also making some internal tools for myself that requires WebGL (map renders with Plotly in Dash).
Is there a way to tell LibreWolf to enable WebGL only for specific sites, so that I don't have to manually toggle this when I want to look at my maps? My initial thought was that this could be solved with a site-specific about:config.
You can use NoScript.
Enable WebGL in LibreWolf/Firefox, block it with NoScript and manage a white list adding manually sites you need.
That seems like a very simple option. Does NoScript in any way interfere with uBlock Origin or any of the settings in LibreWolf? As in, can I just allow everything except WebGL, turn on WebGL in about:config and have the exact same behavior as before?
I use Firefox with uBlock and NoScript plus other addons and seems to be no interference between those two.
Should not be an issue on LibreWolf.