It is true, in a plainly quantitative sense of body counting, that the barrage of disease unleashed by the Europeans among the so-called "virgin soil" populations of the Americas caused more deaths than any other single force of destruction. However, by focusing almost entirely on disease, by displacing responsibility for the mass killing onto an army of invading microbes, contemporary authors increasingly have created the impression that the eradication of those tens of millions of people was inadvertent - a sad, but both inevitable and "unintended consequence" of human migration and progress. This is a modern version of what Alexander Saxton recently has described as the "soft side of anti-Indian racism" that emerged in America in the nineteenth century and that incorporated "expressions of regret over the fate of Indians into narratives that traced the inevitability of their extinction. Ideologically," Saxton adds, "the effect was to exonerate individuals, parties, nations, of any moral blame for what history had decreed." In fact, however, the near-total destruction of the Western Hemisphere's native people was neither inadvertent nor inevitable.

From almost the instant of first human contact between Europe and the Americas firestorms of microbial pestilence and purposeful genocide began laying waste the American natives. Although at times operating independently, for most of the long centuries of devastation that followed 1492, disease and genocide were interdependent forces acting dynamically - whipsawing their victims between plague and violence, each one feeding upon the other, and together driving countless numbers of entire ancient societies to the brink - and often over the brink - of total extermination.

Stannard, D.E. 1992. "American Holocaust: Columbus and the Conquest of the New World." Oxford University Press.