My immediate thought was Harry Harlow's wire mother/rag mother experiments with Rhesus Monkeys (CW: live animal experimentation - https://en.wikipedia.org/wiki/Harry_Harlow#Monkey_studies) which were an early exerpiment showing that it's really, really bad for primates to be socially isolated. A bunch of polar expeditions were demonstrating the same thing about a decade prior.
Recently we've had a whole bunch of movies about men failing the Turing Test regarding their digital waifus - Blade Runner, Her, Ex Machina, Archer. There are like five different TvTropes pages directly related to this question. And you can go back all the way to Hellenic Greece, with the story of Pygmalia and Galatea, to get the OG "Incel falls in love with body pillow" narrative.
You could probably also throw all the movies about women getting catfished/manipulated by con men stealing their inheritance. The same general thing is going on; The con man is creating a fake person and exploiting the victim's need for social interaction and human intimacy to manipulate their behavior. Anyone who has ever seen an older person fall victim to one of these scams knows how shockingly easy it is to manipulate a socially isolated person in to doing very unwise things, and how hard it can be to convince them that they person manipulating them is "fake" and acting to harm them.