I don't think there is a one size fits all answer.

I ask these questions mostly rhetorically, please don't answer anything that would run the risk of doxing yourself unnecessarily.

Do you speak other languages? Which ones? If not, are you willing to put the effort in to learn?

Do you have any career skills, what are they? If you are highly educated and have specialized skills (especially if you are something like an accomplished scientist) then it is a LOT easier.

What kind of lifestyle do you expect? Do you want something comparable to the USA? Do you want a more agrarian lifestyle?

Do you want to retain US citizenship? If not, some countries can be difficult to naturalize at.

For comparison, I left the US when I was very young and have lived my entire adult life in Japan. It's not perfect. While I hold out hope that comrades here will make progress (and we do in some areas), we have existed as lapdogs of the USA for a very long time at this point. Would I recommend it to other people? Honestly, depends.