Though the Dan Harmon show is animated, Rick and Morty had a live-action interpretation in 2021, and it was about as weird as anyone could expect.

To promote its 5th season, Adult Swim released several promos featuring a live-action Rick and Morty, with the characters played by Christopher Lloyd and Jaeden Martell, respectively.

https://youtu.be/nN3TcRmKrJc