Apparently there's a plot point that involves Gaia creating the Ratkin to eradicate humanity's "surplus population" through disease, which has some very uncomfortable implications, especially in the light of the gross indifference to human life that the ruling class has exhibited in the wake of Covid-19.
I realize this is hinged on a lot of assumptions (that this information is accurate in-universe and that Gaia, as the personification of the Earth, serves as a mouthpiece for the creators' environmentalist views), which is why I'm asking.
In some cases, it's a lot worse than that, clan Ravnos was made up mostly of Sinti and Roma people and their clan weakness was literally "you compulsively commit crime". They axed that part in 5th edition, which is at least aware of a lot of the criticism around the old stuff, but the new version of the clan isn't exactly stellar for other reasons.