Walter White. What other mob/cartel boss could actually engineer their criminal product?

Not a main character per se, but Stringer Bell from the wire.

Tom Hagen from the Godfather (not a show, but whatever!)

Probably some supervillain. It's pretty easy to write a character that thinks impossibly far ahead if you don't mind being campy.

Genny and Ciro in Gomorrah, and Don Minu in ZeroZeroZero.