I'll start off with one, Being upset about a breakup that happened hundreds of years ago.
Edit 1:
- Heath death of the universe, Death of the sun, etc, does not count. I feel like focusing on this is an overused point.
Edit 2:
- Loneliness does not count. I feel like we all know immortality means you'll miss people and lose them.
Having to constantly find new hiding places for the blood chalice, and keeping up with all the latest scanning methods so you can develop countermeasures. Your secret is never truly safe.