That depends on how sensitive you are to mushroom spores. Unless you mean "safe" as in, able to grow a culture that's just the mushroom of interest and not some other gross fungus. And the answer to that is definitely, but it's harder if you have carpet or other mold sources. Getting sterile technique down in a house/apartment is pretty tricky but not impossible. If your culture gets contaminated, generally what happens is it turns into a moldy mess, you're not going to accidentally grow a death cap mushroom in your home culture.