I don't trust Windows Defender at all. I use BitchDefender all of the time. I tried Windows Defender for a year and it didn't fill me with confidence.

I also upload to virus total anything from an unknown source. I tried to use Intezer as well but I had many problems with my account that I have up on them. For some reason their server didn't like my account. A brand new account got closed the following day for being inactive for too long. A week later I can reset the password but I can't log in.