gramscyeet [any]

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Joined 4 years ago
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Cake day: October 6th, 2020

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  • gramscyeet [any]tomainHenrietta Lacks
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    4 years ago

    Pretty funny when it happened to a wealthy white dude he could sue and the courts still said, eh. They aren't your cells anymore.

    https://en.wikipedia.org/wiki/Moore_v._Regents_of_the_University_of_California


  • I think this is starkly different. This is taking famous war crimes and repainting them with current corporate aesthetics, pointing out that this violence never ended and showing its still lurking beneath the flat design bullshit aesthetic. The pelosi edits were just taking cultural appropriation to the absurd.

    Like yes this is shock humor but you can read a message out of it at least.






  • gramscyeet [any]tomainBro I just hope you have it
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    4 years ago

    You are correct in this case, it seems like the current antigen tests have a high false negative rate.

    "What about accuracy? The reported rate of false negative results is as high as 50%, which is why antigen tests are not favored by the FDA as a single test for active infection. " -Harvard.edu


  • gramscyeet [any]tomainBro I just hope you have it
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    4 years ago

    Other way around isn't it? They are designed to have as low false negative as possible, a false positive means someone quarantines for two weeks without symptoms while a false negative means a covid positive person is acting like they don't have it.



  • I'm unsure now, I tried to find the article I read that from. Obviously its super hard to get the true material cost of a drug, I dont think Biogen wants that information out there.

    However I did find a light description of their process

    In common with the production other viral vectors, the vectors used to make Zolgensma are produced in adherent cell lines. Working with adherent cell lines requires specialist technologies and systems. For example, stirred tank bioreactors are better suited to the growth of cells in suspension rather than those that are fixed. Production of a single Zolgensma batch takes 30-days Althoff told us, explaining that after cell expansion, triple transfection of HEK293 cells is used to make the adeno associated virus (AAV) vectors. Downstream processes consist of a series of capture and filtration steps used to achieve the desired impurity profile and full/empty capsid ratio all of which require specialist technologies. “We complete the entire process in-house” Althoff said, adding “The process takes approximately 30 days start to finish. Product can be stored for 12 months.”

    Based on this I found an article that breaks down the cost of AAV vector production: https://www.insights.bio/immuno-oncology-insights/journal/article/15/cost-modelling-comparison-of-adherent-multi-trays-with-suspension-and-fixed-bed-bioreactors-for-the-manufacturing-of-gene-therapy-products

    From figure 5 most doses are around 10K$ considering all costs, now we can be super generous and say that zoglmas material cost is something from 10k$ - 100K$ per dose.


  • Literally witnessed a radicalization moment in my RNA bio class watching people learn that zolgensma (SMA cure) costs 2.1 million dollars per dose. A wonderful dilemma, watch your child die before the age of 2, or hopefully have it covered by your insurance. Our prof even was like "yeah they sell what you research back to you for millions, welcome to rna biology"

    The fucking actuarial math going into this drug is insane, it basically is produced for something like ~500K per vial and they basically double that and add the cost "A human makes over their life time" since they are literally giving you a full life.