If you never play multiplayer, you're probably fine. Though the only issue with that is triple A games not letting Anti-Cheats work on Linux for whatever reason.
Other then that, you'll only run into issues when modding Skyrim for the most part. Here's a github page with a step-by-step guide on how to do it; although, far as I can tell it's four years old and might be obsolete.
There's also this post in the Steam Community forums which is two years old at the earliest.
If you never play multiplayer, you're probably fine. Though the only issue with that is triple A games not letting Anti-Cheats work on Linux for whatever reason.
Other then that, you'll only run into issues when modding Skyrim for the most part. Here's a github page with a step-by-step guide on how to do it; although, far as I can tell it's four years old and might be obsolete.
There's also this post in the Steam Community forums which is two years old at the earliest.