Man, the cyberpsycho missions were fucking hilariously broken before they patched it so most of the hacks no longer worked on them. You could essentially one shot literally anyone with the shutdown command one (knocks the target unconscious instantly). So you'd be getting rushed by some screaming homicidal maniac for what should be a mini boss fight of sorts and be able to just end it with BOOP thud
The 390 mg one is also the large. The regular clocks in at 260 I believe, which (while objectively not a small amount) is far more within the realms of sanity. Just don't go all Murica with the sizing and it shouldn't really be much of a concern.