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https://teddit.zaggy.nl/r/Psychonaut/comments/18mth6c/peyote_is_the_darling_of_the_psychedelics/
Honestly this whole thread is a cesspool, pure psychic damage. There are literally functional alternatives, but still these self-enlightened egolords can't keep their fucking hands off an endangered plant. The prevailing attitude looks to be "Its there, so I i am entitled to plunder it"
Edited because I think I misunderstood the argument you're making. Apologies for being a big dummy.
I can absolutely see why commodifying mescaline or rituals associated with constitutes harmful appropriation of indigenous culture against their expressed desires, but I don't see why synthesizing (or growing and extracting at home) a substance outside of the context of its traditional use, and using it privately is harmful. Obviously it's done against the expressed preferences of a culture that has used the chemical for centuries+ but I'm encountering some trouble accepting the notion that a being colonized necessarily prioritizes one people's spiritual belief over private drug use.
If this also completely misses the argument you're making, I apologize.