For me it's Diablo II. Granted I've played my fair share of D2 since launch, and also recently on a private server with a comrade from hexbear, but I still feel like years later the game didn't grab me as much as D1 did.
Granted I don't hate D2, but for a game that I keep coming back to, D1 takes the prize.
Dead Space 3 had impossible sales expectations because of corpos and had a bunch of brobro bullshit that was injected in like the shitty second brobro player and the ex-girlfriend angst, too.