There are a couple paradoxes of our existence as we know it that remain no matter how well we model the universe. And in some cases, as our models get better, we run into more things that we're at a loss to explain.

I think we'd be a lot better off if we got a lot more comfortable saying "I Don't Know" to things, and leaving room in our worldview for the unknown, instead of insisting that we can make up a story that explains everything. Having everything explained can be quite burdensome.