from this sub: https://old.reddit.com/r/TherapeuticKetamine/comments/v4jz1p/weizmann_institute_of_science_ketamine_is_now/
study: https://www.cell.com/neuron/fulltext/S0896-6273(22)00409-3
The Kcnq2 gene encodes for the Kv7.2 protein, a slow-acting, voltage-gated potassium channel that plays a critical role in the regulation of neuronal excitability
glutamatergic drugs VS old anti-depressants which focus on short term neurotransmitters
The researchers then tested ketamine’s effects in combination with an epilepsy drug, retigabine, known to activate potassium channels in the brain. When the drugs were given together, ketamine’s antidepressant effects were significantly enhanced.
an anesthetic and anti-epileptic, chill ass regimen
By revealing a new mechanism of ketamine’s action, the study may make it possible to expand the use ketamine-based drugs. This, in turn, might help these drugs fully deliver on their promise of providing new hope for depression.
boomer millennials: "in my day, we had to treat our depression with a drug that forced you to reckon with ego death and jump down into the timeless abyss from which all existence was generated"
My partner was recommended ketamine after SSRIs, Mood Stabilizers, Anti-Psychotics, and even fucking Vyanyse did nothing for them. (Technically the Vyanyse just made them wired as fuck, but the rest literally had no side effects)
Vyvanse made me feel like a god but I couldn’t possibly see that as sustainable. I woke my partner up at 3am to tell them about a cool book I was reading and how it would be a great source for some paper I was working on
Vyvanse made me feel like a zombie
I'm not 100% sure what dissociation feels like but it sure felt like I was inside my head watching me go about my day