from this sub: https://old.reddit.com/r/TherapeuticKetamine/comments/v4jz1p/weizmann_institute_of_science_ketamine_is_now/
study: https://www.cell.com/neuron/fulltext/S0896-6273(22)00409-3
The Kcnq2 gene encodes for the Kv7.2 protein, a slow-acting, voltage-gated potassium channel that plays a critical role in the regulation of neuronal excitability
glutamatergic drugs VS old anti-depressants which focus on short term neurotransmitters
The researchers then tested ketamine’s effects in combination with an epilepsy drug, retigabine, known to activate potassium channels in the brain. When the drugs were given together, ketamine’s antidepressant effects were significantly enhanced.
an anesthetic and anti-epileptic, chill ass regimen
By revealing a new mechanism of ketamine’s action, the study may make it possible to expand the use ketamine-based drugs. This, in turn, might help these drugs fully deliver on their promise of providing new hope for depression.
boomer millennials: "in my day, we had to treat our depression with a drug that forced you to reckon with ego death and jump down into the timeless abyss from which all existence was generated"
when i was pretty young i was a casual enjoyer of ketamine. i had a good source and would use a modest 100-200 mg every few weeks for recreational purposes. the rave scene was still around so mostly it was for post-MDMA funtimes. besides being my favorite psychedelic, mostly because if feels very mentally controllable, looking back i didn't realize that shit had pulled me out of serious clinical depression at the time. i thought my brain had just changed or something clicked on.