from this sub: https://old.reddit.com/r/TherapeuticKetamine/comments/v4jz1p/weizmann_institute_of_science_ketamine_is_now/
study: https://www.cell.com/neuron/fulltext/S0896-6273(22)00409-3
The Kcnq2 gene encodes for the Kv7.2 protein, a slow-acting, voltage-gated potassium channel that plays a critical role in the regulation of neuronal excitability
glutamatergic drugs VS old anti-depressants which focus on short term neurotransmitters
The researchers then tested ketamine’s effects in combination with an epilepsy drug, retigabine, known to activate potassium channels in the brain. When the drugs were given together, ketamine’s antidepressant effects were significantly enhanced.
an anesthetic and anti-epileptic, chill ass regimen
By revealing a new mechanism of ketamine’s action, the study may make it possible to expand the use ketamine-based drugs. This, in turn, might help these drugs fully deliver on their promise of providing new hope for depression.
boomer millennials: "in my day, we had to treat our depression with a drug that forced you to reckon with ego death and jump down into the timeless abyss from which all existence was generated"
i tried to resist the urge to post this but if you know where/how to get it it should really only be costing 30 a g max for the good stuff. if anyone is charging that much theyre ripping you off or being ripped off themselves
I never bought a gram of ket, I had a guy I would get a point for 10 dollars from and he gave me decent deals on lots of stuff back in the day. Usually pretty high quality too. I just extrapolated it out to the general, "10 dollars a point, get 2 free points If you buy a gram" that you see with other drugs like this (LSD, MDMA mostly)