Here's a good one: you should have Mario, but the mushrooms are like magic mushrooms and he starts tripping out!

Oh, what if you had some realistic characters who got dropped into a situation from a video game and responded realistically to it?

Don't forget to have a Gamer Girl in your comic. She can do all of the Girl things that your guy characters don't want to do, and if money gets real tight you can turn some or all of your strips into wank bait and charge money to view the uncensored versions of them.