Why not go back to God’s drawing board and design better Sapiens? The abilities, needs and desires of Homo sapiens have a genetic basis. And the sapiens genome is no more complex than that of voles and mice. (The mouse genome contains about 2.5 billion nucleobases, the sapiens genome about 2.9 billion bases, meaning that the latter is only 14 percent larger.) … If genetic engineering can create genius mice, why not genius humans? If it can create monogamous voles, why not humans hard-wired to remain faithful to their partners?
Ethics around trying to stamp out poly people aside, I'm sure there would be absolutely no negative side effects from making it harder for people to leave relationships.
And no, I didn't read Sapiens, I got this excerpt from Current Affairs.