Moreover, it is increasingly within the purview of science to alter DNA to suit human needs, so even in that tautology the roles should be reversed eventually.

I guess this is the end goal but what are we altering the DNA to do exactly? Increase chances of survival/better quality of life so that DNA itself can propagate further. I'm not saying that DNA literally lords over you and controls your mind. I'm just identifying that we're a complex mechanism to spread that molecule rather than being the molecule itself. If DNA could spread more efficiently by keeping the body in a constant state of unbearable agony, it would eventually evolve to do so. I'm just advocating you break the illusion of "DNA = me".