For me, I'd have to say Old School X-COM (UFO Defense, TFTD, X-COM Apocalypse to an extent). I love them in a way that I just do not enjoy NewCOM, but the interface was quite possibly based on the recovered works of a 13th century scribe, and is very difficult to get used to for an unfamiliar player.
MOO2 is my sudoku. Played so many hours that it's mostly a solved game for me, and the ease and familiarity makes it kind of zen.