this is vaguely related to the string theory related post from a day or two ago, it's all bazinga science folks TL;DW string theory is a big thing because people that read pop science really liked it and it took a long time for physicists to come out in force and say "this is untestable garbage"
Pickle Rick was the writer directly insulting those people. The joke is that there's no joke, Rick turns himself into a pickle and acts like it's a major accomplishment to get out of a social engagement. Morty immediately sees through this and Rick is left screaming Pickle Rick while a disappointed Morty walks away.
There's not much you can do to tell these people that the things they value in Rick are actually really horrible traits that hurt Rick and everyone he cares about.
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