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Bottles (https://usebottles.com/) is what you're looking for, sandboxing is one of it's primary features. It can use lutris prefixes too if you need them.
EDIT: It's only sandboxed if you use the flatpak, just FYI.
You might find your answers in the link below:
https://github.com/lutris/lutris/issues?q=is%3Aissue+is%3Aopen+sandbox