Obviously all was not fair, but he tried harder than most mayos of the british empire to be fair to natives...
After he died they started getting treated like shit in pennslyvania again...
One looks back and wonders if there were more whites like Penn, could things have been different for the indigenous population?
You're only thinking of the economic incentives. If you let the natives of the land thrive while your mode of life is clear cutting and over consumption, you will inevitably raise the contradiction to the point of violence between the factions. Maybe the Quakers were humble enough to give up European devastation as their standard mode of life, but it's unlikely.