Evidence from observational studies is accumulating, suggesting that the majority of deaths due to SARS-CoV-2 infections are statistically attributable to vitamin D insufficiency and could potentially be prevented by vitamin D supplementation [...]
Part of the brain isn't formed fully and causes an insufficient supply of norepinephrine and dopamine, causing the reward circuits in your brain to not work properly. A normal person may get some baseline amount of dopamine (let X = that baseline) for getting some household chore done, but gets X+20 if they sit around and watch TV while cramming potato chips into their maw. Yeah, watching TV may be more pleasurable, at least in the short term, but getting those other necessary tasks done is rewarding enough that the brain is able to consider them.
For someone with ADHD, it's more of X-20 and X instead. Sitting around watching TV is rewarding enough that you can do it, but getting those necessary tasks done is just going to feel draining and shitty, it's not rewarding enough to your brain to consider it as even an option. It's what leads to the "out of sight, out of mind" problem being a big problem for people with ADHD. My bathroom is a fucking mess, and I know it is, but it's not the thing my brain will consider until I'm actually in the bathroom and looking at the problem - but, like, I'm only in there while using it, the second I leave it, my brain stops considering it again.
Stimulants return the ADHD brain's reward circuits to baseline, so it works like normal. For people without ADHD, it kicks their brain into overdrive, and now even menial tasks seem super exciting and engaging, leading to the stereotypical "took stims, cleaned the bathtub for 8 hours straight for some reason" behavior.
Yeah, that's the part we don't really know to be honest. Our findings thusfar have basically lead us to "it's probably genetic somehow, not much you can do but take meds and learn to cope".
Unlike a lot of health issues, we didn't start with "oh hey, if your brain forms in this specific way, you act weird". Stimulants also have a side effect of dropping your appetite to basically zero, so they were originally being tested as weight loss drugs, when someone realized "hey wait this makes some really hyper kids be normal, wtf?" and we've kinda worked backward from there. This was the original ad for adderall before it rebranded, even - and that was only in the 50s and 60s, so our understanding of all this is still relatively new.
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Part of the brain isn't formed fully and causes an insufficient supply of norepinephrine and dopamine, causing the reward circuits in your brain to not work properly. A normal person may get some baseline amount of dopamine (let X = that baseline) for getting some household chore done, but gets X+20 if they sit around and watch TV while cramming potato chips into their maw. Yeah, watching TV may be more pleasurable, at least in the short term, but getting those other necessary tasks done is rewarding enough that the brain is able to consider them.
For someone with ADHD, it's more of X-20 and X instead. Sitting around watching TV is rewarding enough that you can do it, but getting those necessary tasks done is just going to feel draining and shitty, it's not rewarding enough to your brain to consider it as even an option. It's what leads to the "out of sight, out of mind" problem being a big problem for people with ADHD. My bathroom is a fucking mess, and I know it is, but it's not the thing my brain will consider until I'm actually in the bathroom and looking at the problem - but, like, I'm only in there while using it, the second I leave it, my brain stops considering it again.
Stimulants return the ADHD brain's reward circuits to baseline, so it works like normal. For people without ADHD, it kicks their brain into overdrive, and now even menial tasks seem super exciting and engaging, leading to the stereotypical "took stims, cleaned the bathtub for 8 hours straight for some reason" behavior.
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Yeah, that's the part we don't really know to be honest. Our findings thusfar have basically lead us to "it's probably genetic somehow, not much you can do but take meds and learn to cope".
Unlike a lot of health issues, we didn't start with "oh hey, if your brain forms in this specific way, you act weird". Stimulants also have a side effect of dropping your appetite to basically zero, so they were originally being tested as weight loss drugs, when someone realized "hey wait this makes some really hyper kids be normal, wtf?" and we've kinda worked backward from there. This was the original ad for adderall before it rebranded, even - and that was only in the 50s and 60s, so our understanding of all this is still relatively new.
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