also, killing the carnival barking eugenicist is good times. i tied him up and drowned his ass.

also you can free lots of random prisoners/captives and kill their jailers/bounty hunters... and they usually give you a tip on a rich settler to do some home invasion on.

there's that one encounter in down south where you come up on a camp of those former-confederates-now-a-gang, kill 'em all, and see they had taken a city cop hostage, all tied to a post. he was asking me to cut him free, so i lit him on fire so my heart could dance to the music of his screams.