Idk if there's a better comm for this, but.
Let's say, purely for the sake of argument 
that I am currently on a super-cool prescription painkiller that works great. Let's also say for the sake of argument that the bone/sinew structure that's supposed to hold my ribs together is trying to kill me constantly by conspiring with the base of my skull to cause me unbearable chronic pain. If I skip more than like one day of the cool prescription painkillers, then even just walking around becomes challenging. But also, if I just keep taking the cool prescription painkillers, I'll build up a tolerance. I'm on like 75mg a day right now and even that could be playing with fire.
I need something cool that's gonna dummy out my pain receptors long term. What's a good painkilling solution? I've tried cymbalta, taking way too much paracetamol and ibuprofen, and this cool highly addictive prescription thing. I'm game for any suggestions.
I am not basing it solely on the bottle, but I mentioned that because that's the only info the average person is going to get.
regardless I stand by the therapeutic index being way worse for acetaminophen, and the evidence for its use as a broad spectrum painkiller very spotty. There are certainly issues with nsaids too, but there's a reason acetaminophen is like a leading cause of liver failure
idk why I care, maybe you are right. But its not harmless like many people seem to think
Fair enough
spoiler
I do think a significant number of acetaminophen linked liver failures are due to people taking a bunch intentionally to attempt suicide, but just ending up destroying their liver.