Hopefully I'm preaching to the choir and the main response from everybody is that this is obvious and didn't need to be said.
I read a few comments from some gross cishets about how angry they are about the female Custode. They prop up the Imperium of Man as though they are some paragon of morality and not the picture of everything wrong with imperialism. Naturally this perfectly moral force would have only men in its ranks, clearly! They don't seem to realize that if women are left out we have a sexist/mysogynist system which is not worth praising, and if they include women then it's the imperialist machine trying to keep up appearances. Frankly, I've always figured the Imperium didn't care about gender or race because everyone is suitable to die in combat and be ground into food for the starving populace.
tl;dr Men are upset that women exist and missed the whole satire
There were traces of that from the beginning, but it was also implied that it was actually nothing and the Imperium was seeing things that weren't there because they're ideologically incapable of conceiving of a functioning society, but we know how media literate people who treat lore like encyclopedia facts tend to be.
I've only recently gotten a bit into WH through lore videos while I'm going to sleep so my knowledge is pretty superficial.