• Hexboare [they/them]
      ·
      2 months ago

      I understand that the dosages of semaglutide for diabetes range from 0.25mg to 2mg - are you saying people are injecting 10mg a week? That does seem like a considerable leap

      Th lifetime usage aspect makes them particularly attractive for pharma companies

        • Hexboare [they/them]
          ·
          2 months ago

          Yeah they did another trial (SUSTAIN FORTE) for diabetes after those

          Semaglutide is an effective treatment for type 2 diabetes; however, 20–30% of patients given semaglutide 1·0 mg do not reach glycaemic treatment goals. We aimed to investigate the efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in adults with inadequately controlled type 2 diabetes

          10.1016/S2213-8587(21)00174-1

            • Hexboare [they/them]
              ·
              2 months ago

              Right, but the weight loss increase was also very small

              Mean change in bodyweight from baseline at week 40 was −6·9 kg with semaglutide 2·0 mg and −6·0 kg with semaglutide 1·0 mg

              So glycated haemoglobin improves by 10 percent and weight loss increase by 15 percent.

              This would suggest to me that whatever long term problems are associated with semaglutide at 2mg are probably going to be associated with semaglutide at 1mg at broadly similar rates.

              Time will tell though!