I've actually been traveling the world collecting all of the Diabetes. There's 7 of them and when you get them Ronald McDonald shows up and grants you a wish.
I know not with what drugs Type 3 Diabetes will be fought, but Type 4 Diabetes will be fought with sticks and stones.
This made me laugh so hard dude. Very rare that a post can do that. I’ve been having a kinda shit time too, thanks for the mirth.
Yeah but "type 4 diabetes" is funny.
If you want the actual 10 year medical disaster from Ozempic my bet's on an exciting new kind of liver or pancreas failure.
Nah I wasn’t tryna be a dick, I just genuinely found the idea of type 4 diabetes really funny, and the gallows of humour of how bad ozempik is gonna fuck up an entire generation… it was just a chefs kiss combo for me
Weight loss treatment with GLP-1 is five times the dosage administered to diabetic patients.
It is still far too early to tell if there are long term adverse effects to the people who take them at this level of dosage yet. It’s like taking 5 times the amount of drugs you normally would when prescribed by the physicians, and you have to keep taking them since the effect (lowering appetite and slowing food digestion) is reversible once you stop taking them.
For clinically obese patients, the benefits of weight loss are probably going to outweigh the adverse consequences, but there have been many people who don’t meet the medical criteria and are taking them just for the sake of losing weight.
I understand that the dosages of semaglutide for diabetes range from 0.25mg to 2mg - are you saying people are injecting 10mg a week? That does seem like a considerable leap
Th lifetime usage aspect makes them particularly attractive for pharma companies
All SUSTAIN trials were performed at 0.5mg or 1.0mg, where glycemic control was largely achieved with 0.5mg dose, except for severe patients where lower dosage was inadequate to reach the HbA1c target.
STEP trials for weight loss were done with 2.4mg per week, which is 5 times the dosage normally prescribed for Type 2 diabetes patients.
Yeah they did another trial (SUSTAIN FORTE) for diabetes after those
Semaglutide is an effective treatment for type 2 diabetes; however, 20–30% of patients given semaglutide 1·0 mg do not reach glycaemic treatment goals. We aimed to investigate the efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in adults with inadequately controlled type 2 diabetes
10.1016/S2213-8587(21)00174-1
Yes, one trial in the last 5 years. Which is why I said we’re nowhere close to knowing the long term effect of these dosage. The first SUSTAIN goes back to 2014 and we have about a decade of data. All the STEP trials are within 5 years.
You should also note that going from 1.0mg to 2.0mg (doubling the dosage) improved the HbA1c measure from 1.9% reduction to 2.1%. It’s statistically significant but the effect is also small (an improvement for treating severe patients but not so much for the rest of the disease population). Most of the reduction is in the body weight when increasing the dosage.
Right, but the weight loss increase was also very small
Mean change in bodyweight from baseline at week 40 was −6·9 kg with semaglutide 2·0 mg and −6·0 kg with semaglutide 1·0 mg
So glycated haemoglobin improves by 10 percent and weight loss increase by 15 percent.
This would suggest to me that whatever long term problems are associated with semaglutide at 2mg are probably going to be associated with semaglutide at 1mg at broadly similar rates.
Time will tell though!
I don't wanna be a -truther, I'm just paranoic of the thing being abused/misused cuz right now everyone is getting a prescription for it cuz it's the magic treatment for weight loss.
I just don't want a Opioid Epidemic: Pancreas Shenanigangs Boogaloo
All drugs carry some level of risk, and there are enough rare side effects that you'd want a good reason to take anything, because otherwise you might end up as "Case Report: Rare instance of dissolved organs in 40 year old male treated with semaglutide for weight loss", which would be unfortunate.
I’m imagining 5 dimensional diabetes where Wilford Brimley is talking backwards and phasing in and out of existence
I don't think GDM has a specified "type", for type 1.5 diabetes just think "slow type 1" diabetes
Is there any evidence it's bad though? There's so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population, like vaccines
There's so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population, like vaccines
There's also the precautionary principle, which I think is the best way to approach food and drug safety: the thing in question has to be proven to be safe and contingencies have to be in place in case of harm before being released. This is opposed to the more US approach to food and drug safety, which requires proof that the thing is unsafe to proceed with regulation.
There's so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population
This is just wrong to the point of being harmful misinformation.
Vaccines are probably the most amazing medicine, but they have (usually minor) side effects for basically everyone. I'm not aware of any medicine that doesn't.
but they have (usually minor) side effects for basically everyone
I meant side effects near the magnitude of "type 4 diabetes" haha
Yes, though that vaccine was taken off the market and even in China (that didn't use that particular vaccine) the narcolepsy rate tripled anyway because H1N1 flu can trigger narcolepsy
I get adhd meds so I feel like I should be in on this joke, but I don't get it. Would you explain it for me, please?
Amphetamine was the original (safe) weight loss drug due to it increasing metabolism and suppressing appetite.
Phentermine and fenfluramine are basically worse amphetamines to achieve a similar effect.
The appetite suppression will be less noticeable for many people with ADHD because you could be forgetting to eat and then overeating later when you feel like you're starving
Wilford Brimley will take on that beetus too, ripping and tearing, until it's done.
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look at what they need to mimic a fraction of our power 
