• Hexboare [they/them]
      ·
      2 months ago

      Yeah they did another trial (SUSTAIN FORTE) for diabetes after those

      Semaglutide is an effective treatment for type 2 diabetes; however, 20–30% of patients given semaglutide 1·0 mg do not reach glycaemic treatment goals. We aimed to investigate the efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in adults with inadequately controlled type 2 diabetes

      10.1016/S2213-8587(21)00174-1

        • Hexboare [they/them]
          ·
          2 months ago

          Right, but the weight loss increase was also very small

          Mean change in bodyweight from baseline at week 40 was −6·9 kg with semaglutide 2·0 mg and −6·0 kg with semaglutide 1·0 mg

          So glycated haemoglobin improves by 10 percent and weight loss increase by 15 percent.

          This would suggest to me that whatever long term problems are associated with semaglutide at 2mg are probably going to be associated with semaglutide at 1mg at broadly similar rates.

          Time will tell though!