Yup, you won't get quite the same experience if you haven't played System Erasure's previous game ZeroRanger but I think the parts that made me get really into Void Stranger stand on their own.

The game's puzzles get hard and interesting and there's an entire meta layer of puzzles on top of that that you need to figure out. I'd recommend not looking up anything unless you really can't figure out how to continue at one point since the game does a good job telegraphing most of its secrets.