Advancing Past Early Trials – Plus Shooting for Lifelong Immunity (Next Generation Covid Vax Update 12) - Absolutely Maybe
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A massive funding boost from Project NextGen enables 3 phase 2b trials of next generation Covid vaccines to start in the US…

News from US Project NextGen:

The 3 vaccines from the USA chosen for Project NextGen are:

  • Gritstone Bio’s self-amplifying mRNA vaccine aiming to be “variant-proof”;
  • Covi-Vac/CoviLiv: A live virus intranasal vaccine from Codagenix; and
  • Castlevax viral vector intranasal vaccine, from a Mount Sinai Hospital spin-off.

Mucosal vaccines:

  • Mucosal vaccines are currently authorized for use in 6 countries: China, India, Indonesia, Iran, Morocco, and Russia. There are 5 of these vaccines: China has 2, and one of them is authorized in 3 countries:
    • Ad5-nCoV (Convidecia Air) Viral vector (adenovirus) vaccine by by CanSino (China)
    • BBV154 (iNCOVACC) Viral vector (adenovirus) intranasal vaccine by Bharat Biotech (India), using ChAd-SARS-CoV-2-S by Washington University in St Louis
    • DNS1-RBD (Pneucolin) viral vector intranasal vaccine, by Beijing Wantai BioPharm (China)
    • Razi Cov Pars Protein subunit by Razi Vaccine & Serum Research Institute (Iran)
  • 27 have reached clinical trial, with at least one of those has been discontinued.
  • 6 mucosal vaccines have reached phase 3 trials, including the 5 authorized vaccines.
  • sovietknuckles [they/them]
    ·
    11 months ago

    I need to do more reading about the mucosal vaccines in general. I was under the impression that their efficacy wanes quickly.

    In the case of Razi Cov Pars, the mucosal vaccine that has been out for the longest, it offers protection for up to 5 months. That's an improvement on current mRNA vaccines, which protect against hospitalization for only 4 months (with protection peaking 1 month after you get it and declining from there). But "mucosal" really only describes the delivery route, different types of mucosal vaccines could be designed to be longer-lasting.

    That's one nice thing about variant-proof vaccines, we'll probably need to take them once, or maybe once every couple of decades (if the Tonix variant-proof vaccine works out, at least).