I called it quits after two episodes, but (obvious spoilers) they changed a bunch of shit:

• The Vault on Terminus has some magic forcefield that keeps everyone away except for Salvor Hardin
• Gaal Dornick is psychic
• A trio of clone emperors are in charge, rather than the council led by Eto Demerzel
• Terminus has some sort of killer alien living on it
• There's a (muslim-coded) terrorist attack on a space elevator on Trantor by Anacreon + some other province
• This terrorist attack is the only reason the Encyclopedia Galactica project is allowed to proceed
• Anacreon gets orbitally bombarded by the Empire
• Hari Seldon's adopted son kills him en route to Terminus (rather than him dying of being old on Trantor)
• Gaal Dornick is put into cryosleep and launched into an asteroid belt en route to Terminus
• The existence of robots is common knowledge, and the emperor knows that Demerzel is a robot

Other really minor decisions I just don't care for:

• People have to be drugged unconscious during hyperspace travel, except for what I'm assuming are mutated humans who pilot ships
• The Imperial Library is full of paper books rather than digital spacebooks
• They have a holodeck where they simulate fighting the killer Terminus alien. The two main characters later fuck on the (public) holodeck.
• Terminus seems to be an ice world, rather than mostly water-covered with little landmass
• The Prime Radiant looks wrong; instead of projecting equations onto walls, it's just a weird magic space ball of light

I understand that they'd have to add stuff (the books are pretty lacking in characterization or women characters, for instance), but it felt like they gave up on adapting the book and just started writing fan-fiction. Also for some reason they plan to do fucking 8 seasons, which means they're going to have to stretch the material ridiculously thin.