Mine would be arbitrarily slowing down a character to maintain horror in a game. I get if there are reasons like age, injury, or location that could provide context, but don't turn my legs into molasses because you need to time the jump scare just right.
as much as I love Pathologic, this one in particular grinds away at me. The main character should potentially be able to get by without eating for a few days at least, but starts to starve in less than one.
It could probably be excused by the whole supernatural plague thing, but it's still annoying.
Then again, Pathologic exists to make the player unhappy