A senior commander of an Iran-backed militia has been killed in a US drone strike in Baghdad.
A leader of Kataib Hezbollah and two of his guards were in a vehicle when it was targeted in the east of the Iraqi capital. All three of them died.
The Pentagon said the commander was responsible for directing attacks on American forces in the region.
The US has linked the militia to a drone attack in Jordan that killed three US troops last month.
In the wake of that attack, Kataib Hezbollah said it was suspending attacks on American troops to prevent "embarrassment" to the Iraqi government.
Wednesday night's drone raid happened in Baghdad's Mashtal neighbourhood, sparking several loud explosions.
It was a precise strike on a moving vehicle in a busy street and the car was reduced to a fiery wreck.
One of the victims has been identified as Abu Baqir al-Saadi, a senior commander in Kataib Hezbollah.
US Central Command (Centcom) said the attack was carried out at 21:30 local time (18:30 GMT), and had killed the "commander responsible for directly planning and participating in attacks on US forces in the region".
"There are no indications of collateral damage or civilian casualties at this time," the Centcom statement said.
When a BBC team reached the scene, crowds of protesters gathered chanting: "America is the biggest devil."
There was a heavy police presence, joined by Swat teams from Iraq's interior ministry.
The BBC team tried to get close to the burnt-out vehicle, but were driven back by onlookers who insisted that journalists were not welcome.
"You are foreigners," one man shouted, adding "and foreigners are to blame for this".
There were reports of crowds heading to the heavily fortified US embassy to protest.
The raid comes days after the US launched 85 strikes in Syria and Iraq in retaliation for the fatal 28 January drone attack on US troops.
President Joe Biden described last Friday's wave of attacks as just the beginning of the US response.
The drone raid in the Iraqi capital will be seen as a major escalation in the US response. Previous strikes have only targeted the Iraq-Syria border area.
But it was perhaps inevitable that the American strategy would include targeting not only infrastructure used by the groups, but also their senior leaders.
Shortly after Wednesday's attack, militias in the country called for retaliation against the US.
American forces have been hit with near-daily rocket and drone strikes since the Israel Gaza war began on 7 October.
On 4 January, the US launched an airstrike in Baghdad against the leader of Harakat al Nujaba, a group also blamed for attacks against American troops.
The US has some 2,500 troops in Iraq and 900 in neighbouring Syria in a mission to combat the Islamic State terror group.
When a BBC team reached the scene, crowds of protesters gathered chanting: "America is the biggest devil."
There was a heavy police presence, joined by Swat teams from Iraq's interior ministry.
The BBC team tried to get close to the burnt-out vehicle, but were driven back by onlookers who insisted that journalists were not welcome.
"You are foreigners," one man shouted, adding "and foreigners are to blame for this".
There were reports of crowds heading to the heavily fortified US embassy to protest.
Hearts and minds. Genocide Joe's most progressive administration of all time stay winning.
There are people who say "Sure the west has its problems, but it's the most moral and human hegemone and so it's good that it remain in power."
Funny enough, whenever someone says this to me, it's always someone who lives in the imperial core
Words never said by somebody who paid the price for assertion of interest.
A sentiment by and for the historically illiterate
A truly evil man, for he seems to not even care about the human costs, only about American interests.
Odd on it actually being some random aid worker and his family like that one time in Kabul?
I feel like this is a martyr. The resistance would hav called it out as targeting aid workers if that was the case. The resistance is yet to lie. If they are silent on this I believe it is because they lack incentive to speak. For they are above lying to gain short term advantages, the long term of always speaking true is more valuable. NF style
There's no way this could end badly. Blowback shmoeback
Biden really really wants to see the nukes fly before he kicks it
it is an election year, the United States has assassinated an Iranian military leader
