When people struggle in clinical trials, or when someone goes to the ER for a bad time with psychedelics recreationally, doctors typically administer benzodiazepines to calm their anxiety and tone down the trip. Anecdotally, this is said to kill the "headspace" of the trip almost entirely even as some other aspects, like visual disturbances, persist.

Sometimes doctors will offer to prescribe a few benzos to patients with anxiety when they describe a specific limited scenario that triggers panic attacks, such as an upcoming flight that will be complicated by an intense phobia of flying.