At least I hope if it spreads a ton, people will take it seriously because it makes you look like a leper and long monkeypox complications include chronic sepsis and bronchopneumonia, along with permanent blindness.
But if COVID 19 is anything to go by, everyone except China will be pretty fucked until the vaccines and antivirals roll out...
The vaccine is gnarly though, Chud antivaxxers are going to freak. Ask people that served in the US military after 9/11 about the smallpox vaccine, it's like over a dozen needles and gives you a big wart. 1 in 10 000 chance of heart inflammation as well.
Still much, much more preferable to get the vaccine if this spreads.
I knew a guy who got it and the one big rule was DO NOT SCRATCH THE PUNCTURE SITE. So, naturally, he did, and it spread all over his arm and upper chest. He got written up for it.
It wasn't "over a dozen needles," either -- just a jabby thing that they stab into your upper arm a few times. It scabs over after a day or two, itches like hell, and then eventually the scab falls off and you're more or less immune to smallpox.
But yeah, CHUDs are going to flip their shit if vaccinia virus is one of the vaccines that the WHO and CDC say are viable for monkeypox prevention. IT'S RIGHT THERE IN THE NAME!
It seems that the vaccine being ordered is a new smallpox vaccine that uses the single needle intermuscular injection now, and not the stabby Y thing a few times, got approved in 2019.
People with weakened immune systems or skin conditions, such as atopic dermatitis, or eczema, are at increased risk for serious side effects from Dryvax and Acam2000. NIAID is pursuing the development of new, safer smallpox vaccines that could be used to protect these groups. One candidate developed by the biotechnology company Bavarian Nordic uses a vaccine platform technology known as Modified Vaccinia Ankara – Bavarian Nordic (MVA-BN). NIAID supported early advanced development work for this important vaccine, with initial efforts largely focused on the liquid formulation. NIAID supported preclinical evaluation through Phase II clinical trials of the investigational vaccine. The trials assessed the vaccine in healthy participants, HIV-positive volunteers, and people with atopic dermatitis or a history of atopic dermatitis. These studies evaluated safety, immunogenicity, duration of protection, and route of vaccination.
Following promising clinical trials results, MVA-BN was transitioned to the Biomedical Advanced Research and Development Authority (BARDA) for advanced development. In 2013, Canada and the European Union approved the vaccine (under the trade names IMVAMUNE and IMVANEX) for use in the general population, including people with weakened immune systems or atopic dermatitis. As of August 2014, 24 million doses were delivered to the U.S. Strategic National Stockpile (SNS) for use among these groups. BARDA also supported large Phase 3 clinical trials of the vaccine. Based on promising data from these studies, the FDA approved MVA-BN (now called JYNNEOS) in September 2019.
That's a much better source, I was trying to decipher the incomprehensible Wikipedia page and the Bavarian Nordic website and PDFs. Which were worded very poorly. Will update my comments, thanks for the correction
The Wikipedia page literally says that the MVA-BN vaccine is unsafe for eczema, which is straight up false, wtf lol.
Also there's so much redacted stuff on the PDFs on the Bavarian Nordic website it's impossible to read. I found an interesting pdf there about a simulated bioterrorist monkeypox attack on May 15 2022 lmao. Obviously the simulation was made after the June 2021 monkeypox outbreak in Nigeria, and it's just a coincidence, but pretty funny in a :illuminati: way
It doesn't, but it does use really fucking confusing wording/nonsensical proximity. Here:
MVA-BN contains Modified vaccinia Ankara, an attenuated form of the vaccinia virus that does not replicate in human cells and hence does not cause the sometimes serious side effects that are seen with replicating smallpox vaccines (i.e. preparations of unattenuated vaccinia virus). These replicating vaccines use different strains of the vaccinia virus, which all replicate in humans, and are not recommended for people with immune deficiencies and exfoliative skin disorders, such as eczema or atopic dermatitis. Vaccines containing vaccinia viruses were used effectively in the campaign to eradicate smallpox. Because of similarities between vaccinia and the smallpox virus, the antibodies produced against vaccinia have been shown to protect against smallpox. In contrast to replicating smallpox vaccines, which are applied by scarification using a bifurcated needle, MVA-BN is administered by injection via the subcutaneous route.[32]
Emphasis mine.
The "These replicating vaccines..." part is referring to Dryvax and ACAM2000 (replicating vaccines). It starts out by stating that MVA-BN is non-replicating, and then goes off on a tangent about replicating variants, which still sounds like it's talking about MVA-BN. The next two sentences are just redundant with the entire article, and shouldn't even be there. That section should have been edited for clarity, because yeah, if you are skimming, it's easy to miss that distinction when three quarters of the fucking paragraph is talking about something that is not applicable to MVA-BN.
From the article about the US ordering the vaccines, it looks like they are ordering the Jynneos vaccine specifically. According to the Wikipedia article at least, Jynneos is administered subcutaneously rather than via scarification, although I haven't read that much into it yet, so it may still cause the same reaction at the injection site. So maybe that will help things, but even in the best case, I know antivaxxers are going to be a huge problem if this starts spreading
I hope it can be contained enough that it won't come to mass vaccination, but after covid I'm not super confident in that anymore. The two injections spaced a month apart should be familiar to people from covid at least. This was the source linked to on wikipedia if you happen to want to read into it more (just a warning, it's a PDF). I wish I could be hopeful that proper measures will be taken ( :xi-plz: ). Maybe the fact that the infection is very visible will help clamp down on people claiming it's fake, but again, it's hard to be sure about anything these days
I legitimately started doing this a couple weeks ago for this reason. Not banking on living there, but if I could just visit occasionally and be in public spaces with other people without worrying that I'm gonna fucking die...
From that Wiki article, Jynneos uses a live but non-replicating (and milder) form of vaccinia, so it's supposed to be safe for people with eczema. The section in the wiki is unclear as all hell and looks like it was copied and pasted from a marketing brochure, but the word salad is just stating that ACAM2000 and Dryvax were unsafe for patients with skin conditions, not that Jynneos is.
I think it was just lifted straight from that NIH page that I linked below with no regard for sentence structure or context, but yeah, we'll have to see what the CDC says in the US. I'm sure Fauci will find a way to fumble it.
Wikipedia used to be really good for medical topics and scientists because odds were good the actual scientist specializing in whatever it was you wanted to research wrote the damn entry.
The problem is that the neckbeards cannot distinguish between redundancy and subtle but critical differences, and know absolutely no science whatsoever, so they would merge or delete articles about completely different topics because they thought it was about the same thing. And since seniority and unemployment are the only things that matter when Wikipedia editors have a dispute, the idiots won.
Long story short, most of the really good Wikipedia articles I had bookmarked from ten years ago are trashed and incoherent or flat out gone now.
At least I hope if it spreads a ton, people will take it seriously because it makes you look like a leper and long monkeypox complications include chronic sepsis and bronchopneumonia, along with permanent blindness.
But if COVID 19 is anything to go by, everyone except China will be pretty fucked until the vaccines and antivirals roll out...
Oh, heh, so it wrecks your shit and people are already sick and tired of pandemics and completely done with pandemic protocols? Heh :this-is-fine:
According to the WHO, case fatality rate is 3-6% on average in modern epidemics.
Also everyone's immune systems just got wrecked by COVID so yeah
At least we don't have to wait on the development of a vaccine for this one, if nothing else
The vaccine is gnarly though, Chud antivaxxers are going to freak. Ask people that served in the US military after 9/11 about the smallpox vaccine, it's like over a dozen needles and gives you a big wart. 1 in 10 000 chance of heart inflammation as well.
Still much, much more preferable to get the vaccine if this spreads.
I knew a guy who got it and the one big rule was DO NOT SCRATCH THE PUNCTURE SITE. So, naturally, he did, and it spread all over his arm and upper chest. He got written up for it.
It wasn't "over a dozen needles," either -- just a jabby thing that they stab into your upper arm a few times. It scabs over after a day or two, itches like hell, and then eventually the scab falls off and you're more or less immune to smallpox.
But yeah, CHUDs are going to flip their shit if vaccinia virus is one of the vaccines that the WHO and CDC say are viable for monkeypox prevention. IT'S RIGHT THERE IN THE NAME!
It seems that the vaccine being ordered is a new smallpox vaccine that uses the single needle intermuscular injection now, and not the stabby Y thing a few times, got approved in 2019.
What's your source on the eczema part? The NIH says the opposite, at least in the EU:
https://www.niaid.nih.gov/diseases-conditions/smallpox-vaccine
(Bolded emphasis mine)
That's a much better source, I was trying to decipher the incomprehensible Wikipedia page and the Bavarian Nordic website and PDFs. Which were worded very poorly. Will update my comments, thanks for the correction
No worries; it's actually the same source that the garbled section of the wiki cites. What a clusterfuck, lol
The Wikipedia page literally says that the MVA-BN vaccine is unsafe for eczema, which is straight up false, wtf lol.
Also there's so much redacted stuff on the PDFs on the Bavarian Nordic website it's impossible to read. I found an interesting pdf there about a simulated bioterrorist monkeypox attack on May 15 2022 lmao. Obviously the simulation was made after the June 2021 monkeypox outbreak in Nigeria, and it's just a coincidence, but pretty funny in a :illuminati: way
Yeah, like that totally coincidental SARS-COVID-1 simulation they did in fall 2019
https://hexbear.net/post/195563
It's extremely outlandish, apparently terrorists are going to modify the monkeypox virus to be vaccine resistant
uncritical support for calling the United States government 'terrorists'
Based NGOS?!?!?!!11
It doesn't, but it does use really fucking confusing wording/nonsensical proximity. Here:
Emphasis mine.
The "These replicating vaccines..." part is referring to Dryvax and ACAM2000 (replicating vaccines). It starts out by stating that MVA-BN is non-replicating, and then goes off on a tangent about replicating variants, which still sounds like it's talking about MVA-BN. The next two sentences are just redundant with the entire article, and shouldn't even be there. That section should have been edited for clarity, because yeah, if you are skimming, it's easy to miss that distinction when three quarters of the fucking paragraph is talking about something that is not applicable to MVA-BN.
The military used a trident syringe for smallpox vaccinations, but that would have been pre-1980.
From the article about the US ordering the vaccines, it looks like they are ordering the Jynneos vaccine specifically. According to the Wikipedia article at least, Jynneos is administered subcutaneously rather than via scarification, although I haven't read that much into it yet, so it may still cause the same reaction at the injection site. So maybe that will help things, but even in the best case, I know antivaxxers are going to be a huge problem if this starts spreading
It's still a live vaccine, but should be much better than earlier vaccines though.
I hope it can be contained enough that it won't come to mass vaccination, but after covid I'm not super confident in that anymore. The two injections spaced a month apart should be familiar to people from covid at least. This was the source linked to on wikipedia if you happen to want to read into it more (just a warning, it's a PDF). I wish I could be hopeful that proper measures will be taken ( :xi-plz: ). Maybe the fact that the infection is very visible will help clamp down on people claiming it's fake, but again, it's hard to be sure about anything these days
Time to learn Chinese so we can get to live in a country not ravaged by disease
I legitimately started doing this a couple weeks ago for this reason. Not banking on living there, but if I could just visit occasionally and be in public spaces with other people without worrying that I'm gonna fucking die...
Lol if I wasn't already trying to learn Spanish, I probably would honestly
From that Wiki article, Jynneos uses a live but non-replicating (and milder) form of vaccinia, so it's supposed to be safe for people with eczema. The section in the wiki is unclear as all hell and looks like it was copied and pasted from a marketing brochure, but the word salad is just stating that ACAM2000 and Dryvax were unsafe for patients with skin conditions, not that Jynneos is.
I mean we have to wait on what the health experts say, the Wikipedia page is straight up contradictory.
I think it was just lifted straight from that NIH page that I linked below with no regard for sentence structure or context, but yeah, we'll have to see what the CDC says in the US. I'm sure Fauci will find a way to fumble it.
Edit: He so fucking did. "Blame teh gays lol"
Wikipedia used to be really good for medical topics and scientists because odds were good the actual scientist specializing in whatever it was you wanted to research wrote the damn entry.
The problem is that the neckbeards cannot distinguish between redundancy and subtle but critical differences, and know absolutely no science whatsoever, so they would merge or delete articles about completely different topics because they thought it was about the same thing. And since seniority and unemployment are the only things that matter when Wikipedia editors have a dispute, the idiots won.
Long story short, most of the really good Wikipedia articles I had bookmarked from ten years ago are trashed and incoherent or flat out gone now.
That's good news for anyone with eczema/psoriasis that wouldn't have been able to get the ACAM2000 version, now that Dryvax is gone.